Closing in on the new coronavirus

The eye-catching spikes sticking out from the surface of SARS-CoV-2 may inspire new ways to prevent or treat Covid-19 infections

(20 Mar 2020, feed from Knowable Magazine) It is new, but not entirely. The coronavirus upending the world right now is so similar to the severe acute respiratory syndrome (SARS) virus of 2002–03 that virologists opted to simply call it SARS-CoV-2.

Yet there seem to be some crucial differences between the virus that caused an epidemic 17 years ago and the one causing a global pandemic today. The good news is that relative to the number of infections, the virus does not seem to be quite as deadly as the earlier SARS virus was. SARS-CoV-1 infected around 8,000 people and killed roughly 1 in 7, whereas the estimated death rate for known cases of SARS-CoV-2 — while still uncertain — is much lower, perhaps even less than 1 in 70.

To understand the reasons for these differences, researchers are intensively studying the three-dimensional structure of the viral proteins and, in particular, the ones it uses to infect human cells and reproduce inside them. Such knowledge might offer vital clues for developing therapies and a vaccine — some of which are already being tested.

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